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Molecule Parameter List for A_B

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
A_B participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences2306812

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    strong_coupling
  • 64Network
    Shared_Object_AMPAR_CaMKII_strong_coupling CaMKII CaM 
    PP1 AMPAR_memb PP2B 
    PKA AC PP1_PSD 
    AMPAR 
    This is a model of tight coupling between the AMPAR trafficking bistability, and the CaMKII autophosphorylation bistability. In this model, the CaMKII activity is self sustaining only when AMPAR is turned on. Further, CaMKII turns on when AMPAR is turned on.

    A_B acting as a Molecule in  
    AMPAR_CaMKII_strong_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    A_B
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • AMPAR
    Pathway No. : 280
    00.09No
    A_B
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • AMPAR_memb
    Pathway No. : 275
    00.01No

    A_B acting as a Summed Molecule in  
    AMPAR_CaMKII_strong_coupling Network
     Accession NanePathway NameTargetInput
    1
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • Ser845A_B
    A831*_B
    A_B831*
    A831*_B831*
    2
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • Ser831A845*_B845*
    A_B845*
    A845*_B
    A_B
    3
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • I_845A831*_B831*
    A_B831*
    A831*_B
    A_B

    A_B acting as a Substrate for an Enzyme in  
    AMPAR_CaMKII_strong_coupling Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKA-active  /
    PKA[17]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A845*_B
    2PKA-active  /
    PKA[20]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A_B845*
    3PKA-active  /
    PKA[2]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A845*_B
    4PKA-active  /
    PKA[3]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A_B845*
    5actCaMKII-PSD  /
    CaMKII[3]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 90.00060.54explicit E-S complexSubstrate
    A_B

    Product
    A831*_B
    6actCaMKII-PSD  /
    CaMKII[7]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 90.00060.54explicit E-S complexSubstrate
    A_B

    Product
    A_B831*

    A_B acting as a Product of an Enzyme in  
    AMPAR_CaMKII_strong_coupling Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PP1-active_PSD  /
    PP1[2]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 0.9714510.174explicit E-S complexSubstrate
    A845*_B

    Product
    A_B
    2PP1-active_PSD  /
    PP1[3]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 0.9714510.174explicit E-S complexSubstrate
    A_B845*

    Product
    A_B
    3PP1-active_PSD  /
    PP1[11]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 2.000050.354explicit E-S complexSubstrate
    A831*_B

    Product
    A_B
    4PP1-active_PSD  /
    PP1[23]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 2.000050.354explicit E-S complexSubstrate
    A_B831*

    Product
    A_B
    5CaM_Ca_n-CaNAB  /
    PP2B[17]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 4.9706124explicit E-S complexSubstrate
    A845*_B

    Product
    A_B
    6CaM_Ca_n-CaNAB  /
    PP2B[21]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 4.9706124explicit E-S complexSubstrate
    A_B845*

    Product
    A_B
    7CaM_Ca_n-CaNAB  /
    PP2B[2]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 4.9706124explicit E-S complexSubstrate
    A_B845*

    Product
    A_B
    8CaM_Ca_n-CaNAB  /
    PP2B[3]
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 4.9706124explicit E-S complexSubstrate
    A845*_B

    Product
    A_B

    A_B acting as a Substrate in a reaction in  
    AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    recycle__
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • AMPAR
    Pathway No. : 280
    0.0008
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-Substrate
    A_B

    Product
    A_B
    Anchor
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    A_B acting as a Product in a reaction in  
    AMPAR_CaMKII_strong_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1recycle__
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • AMPAR
    Pathway No. : 280
    0.0008
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-Substrate
    A_B

    Product
    A_B
    Anchor
    2turnover
  • AMPAR_CaMKII_
    strong_coupling

    Accession No. : 64
  • Shared_Object_
    AMPAR_CaMKII_
    strong_coupling

    Pathway No. : 271
  • 0.018
    (s^-1)
    1
    (s^-1)
    Not applicable**-Substrate
    AMPAR_bulk

    Product
    A_B
      Represents both synthesis and degradation of the receptor. The rate is set to be rather fast for now. The forward rate also includes scaling terms because the AMPAR_bulk is in the dendritic volume of 5e-18. This means that we need to lower Kf to account for the difference in volumes. Effectively Kf is 1/sec, but the scaled version becomes 9e-20/5e-18 = 0.018
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



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