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Molecule Parameter List for IFNRJ2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IFNRJ2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000015

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
SOCS1_knockout67Pathway
SOCS1_knockout 
This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

IFNRJ2 acting as a Molecule in  
SOCS1_knockout Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
IFNRJ2SOCS1_knockout
Accession No. : 67
SOCS1_knockout
Pathway No. : 294
00.0016667No
Dimer of IFN gamma liganding to the IFN gamma receptor that has JAK bound to its intracellular domain Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

IFNRJ2 acting as a Substrate in a reaction in  
SOCS1_knockout Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
  • IFNRJ_
    activation
  • SOCS1_knockout
    Accession No. : 67
    SOCS1_knockout
    Pathway No. : 294
    0.005
    (s^-1)
    0
    (s^-1)
    --Substrate
    IFNRJ2

    Product
    IFNRJ2*
    Dimerisation of the RJ complex leads to the phosphorylation of several tyrosine residues by JAK Kf = 0.005*10e+06 /M/sec = 0.005/uM/sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

    IFNRJ2 acting as a Product in a reaction in  
    SOCS1_knockout Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • IFNRJ_
    dimerisation
  • SOCS1_knockout
    Accession No. : 67
    SOCS1_knockout
    Pathway No. : 294
    40
    (uM^-1 s^-1)
    0.2
    (s^-1)
    Kd(bf) = 0.005(uM)-Substrate
    IFNRJ
    IFNRJ_

    Product
    IFNRJ2
      Dimerisation of the RJ complex Kf = 40*10e+06 /M/sec = 40/uM/sec Kb = 0.2 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    2
  • IFNRJ2*_
    dephosphorylatio
    n
  • SOCS1_knockout
    Accession No. : 67
    SOCS1_knockout
    Pathway No. : 294
    0.003
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    IFNRJ2*-SHP-2

    Product
    IFNRJ2
    SHP-2
      SHP-2 dephosphorylates JAK-IFNR dimer Kf = 0.003 /sec Kb = 0 /uM/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
    3
  • dephospo_
    IFNRJ2*
  • SOCS1_knockout
    Accession No. : 67
    SOCS1_knockout
    Pathway No. : 294
    0.003
    (s^-1)
    0
    (uM^-2 s^-1)
    --Substrate
  • IFNRJ2*-STAT1c-S
    HP2


    Product
    IFNRJ2
    SHP-2
    STAT1c
  •   Dephosphoryaltion of IFNRJ2* kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    4
  • Disso_
    SOCS1-IFNRJ2*-SH
    P2
  • SOCS1_knockout
    Accession No. : 67
    SOCS1_knockout
    Pathway No. : 294
    0.003
    (s^-1)
    0
    (uM^-2 s^-1)
    --Substrate
  • SOCS1-IFNR2*-SHP
    2


    Product
    IFNRJ2
    SHP-2
    SOCS1
  •   Dissociation reaction of SOCS1-IFNRJ2*-SHP2 kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
    5
  • IFNRJ2*_
    dephospo
  • SOCS1_knockout
    Accession No. : 67
    SOCS1_knockout
    Pathway No. : 294
    0.003
    (s^-1)
    0
    (uM^-3 s^-1)
    --Substrate
  • SOCS1-IFNRJ2*-ST
    AT1c-SHP-2


    Product
    IFNRJ2
    SHP-2
    SOCS1
    STAT1c
  •   SHP-2 dephosphorylates JAK-IFNR dimer complexed with SOCS1 and STAT1c Kf = 0.003 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196



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