|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for GEF* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2007_ReacDiff1_
1e-13 | 82 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13,
PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1],
PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3],
PKC, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5],
PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[7],
PKC, MAPK, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9],
PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11],
PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13],
PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15],
PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17],
PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19],
PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21],
PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23],
PKC, MAPK, Ras, CaM, PKM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.
|
GEF* acting as a Molecule in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 529 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 536 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 542 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 548 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 554 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 560 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 566 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 572 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 578 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 584 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 590 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 596 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 602 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 608 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 614 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 620 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 626 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 632 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 638 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 644 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 650 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 656 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 662 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 668 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. | | GEF* | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Ras
Pathway No. : 674 | 0 | 1.5 | No | | phosphorylated and thereby activated form of GEF. See, e.g. Orita et al JBC 268:34 25542-25546 1993, Gulbins et al. It is not clear whether there is major specificity for tyr or ser/thr. |
GEF* acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
GEF* acting as a Product of an Enzyme in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Pathway No. : 526 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 2 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics
Pathway No. : 533 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 3 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[1]
Pathway No. : 539 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 4 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[2]
Pathway No. : 545 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 5 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[3]
Pathway No. : 551 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 6 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[4]
Pathway No. : 557 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 7 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[5]
Pathway No. : 563 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 8 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[6]
Pathway No. : 567 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 9 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[7]
Pathway No. : 575 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 10 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[8]
Pathway No. : 581 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 11 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[9]
Pathway No. : 587 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 12 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[10]
Pathway No. : 593 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 13 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[11]
Pathway No. : 599 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 14 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[12]
Pathway No. : 605 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 15 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[13]
Pathway No. : 611 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 16 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[14]
Pathway No. : 617 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 17 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[15]
Pathway No. : 623 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 18 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[16]
Pathway No. : 629 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 19 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[17]
Pathway No. : 635 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 20 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[18]
Pathway No. : 641 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 21 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[19]
Pathway No. : 647 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 22 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[20]
Pathway No. : 653 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 23 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[21]
Pathway No. : 659 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 24 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[22]
Pathway No. : 665 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 25 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff1_
1e-13
Accession No. : 82 | kinetics[23]
Pathway No. : 671 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X |
GEF* acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
GEF* acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
