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Molecule Parameter List for DAG

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
DAG participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences250000500

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    		• 82NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff1_1e-13,  
    PKC,  MAPK,  Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[3],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[5],  
    PKC,  MAPK,  Ras,  kinetics[6],  CaM,  PKM,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[7],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[8],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[9],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  
    PKC,  MAPK,  Ras,  CaM,  PKM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
    The stimulus file pkm_mapk22_diff_1e-13_Fig4B which was used for the model to replicate Figure 4B from the paper.
    pkm_mapk22_diff_1e-13_Fig4H replicate Figure 4H.
    pkm_mapk22_diff_1e-13_Fig4I replicate Figure 4I.

    DAG acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Pathway No. : 526
    		• 12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics
    Pathway No. : 533    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[1]
    Pathway No. : 539    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[2]
    Pathway No. : 545    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[3]
    Pathway No. : 551    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[4]
    Pathway No. : 557    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[5]
    Pathway No. : 563    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[6]
    Pathway No. : 567    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[7]
    Pathway No. : 575    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[8]
    Pathway No. : 581    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[9]
    Pathway No. : 587    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[10]
    Pathway No. : 593    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[11]
    Pathway No. : 599    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[12]
    Pathway No. : 605    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[13]
    Pathway No. : 611    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[14]
    Pathway No. : 617    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[15]
    Pathway No. : 623    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[16]
    Pathway No. : 629    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[17]
    Pathway No. : 635    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[18]
    Pathway No. : 641    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[19]
    Pathway No. : 647    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[20]
    Pathway No. : 653    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[21]
    Pathway No. : 659    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[22]
    Pathway No. : 665    		12.21.5Yes
    DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• kinetics[23]
    Pathway No. : 671    		12.21.5Yes

    DAG acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff1_1e-13 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 527    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    2PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 527    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    3PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 534    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    4PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 534    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    5PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 552    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    6PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 540    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    7PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 540    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    8PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 546    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    9PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 546    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    10PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 576    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    11PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 552    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    12PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 558    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    13PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 558    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    14PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 564    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    15PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 564    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    16PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 570    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    17PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 570    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    18PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 624    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    19PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 624    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    20PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 576    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    21PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 582    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    22PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 582    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    23PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 588    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    24PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 588    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    25PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 594    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    26PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 594    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    27PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 600    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    28PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 600    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    29PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 606    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    30PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 606    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    31PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 612    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    32PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 612    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    33PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 618    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    34PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 618    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    35PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 630    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    36PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 630    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    37PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 636    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    38PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 636    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    39PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 642    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    40PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 642    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    41PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 648    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    42PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 648    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    43PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 654    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    44PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 654    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    45PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 660    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    46PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 660    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    47PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 666    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    48PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 666    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
    49PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 672    		0.008
    (uM^-1 s^-1)    		8.6348
    (s^-1)    		Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    50PKC-n-DAG
  • Ajay_Bhalla_
    2007_ReacDiff1_
    1e-13
    Accession No. : 82
    		• PKC
    Pathway No. : 672    		0.0006
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 166.6664(uM)-Substrate
    DAG
    PKC-cytosolic

    Product
    PKC-DAG
      kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9


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