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Molecule Parameter List for GAP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
GAP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences400404003979

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff2
  • 83NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff PKC MAPK 
    Ras CaM PKM chain kinetics PKC MAPK Ras CaM PKM kinetics[1] 
    PKC MAPK Ras kinetics[3] CaM PKM kinetics[2] PKC MAPK Ras 
    CaM PKM PKC MAPK Ras CaM PKM kinetics[4] PKC MAPK Ras CaM 
    PKM kinetics[5] PKC MAPK Ras CaM PKM kinetics[6] PKC MAPK 
    Ras CaM PKM kinetics[7] PKC MAPK Ras CaM PKM kinetics[8] 
    PKC MAPK Ras CaM PKM kinetics[9] PKC MAPK Ras CaM PKM kinetics[10] 
    PKC MAPK Ras CaM PKM kinetics[11] PKC MAPK Ras CaM PKM kinetics[12] 
    PKC MAPK Ras CaM PKM kinetics[13] PKC MAPK Ras CaM PKM kinetics[14] 
    PKC MAPK Ras CaM PKM kinetics[15] PKC MAPK Ras CaM PKM kinetics[16] 
    PKC MAPK Ras CaM PKM kinetics[17] PKC MAPK Ras CaM PKM kinetics[18] 
    PKC MAPK Ras CaM PKM kinetics[19] PKC MAPK Ras CaM PKM kinetics[20] 
    PKC MAPK Ras CaM PKM kinetics[21] PKC MAPK Ras CaM PKM kinetics[22] 
    PKC MAPK Ras CaM PKM kinetics[23] PKC MAPK Ras CaM PKM kinetics[24] 
    PKC MAPK Ras CaM PKM kinetics[25] PKC MAPK Ras CaM PKM kinetics[26] 
    PKC MAPK Ras CaM PKM kinetics[27] PKC MAPK Ras CaM PKM kinetics[28] 
    PKC MAPK Ras CaM PKM kinetics[29] PKC MAPK Ras CaM PKM kinetics[30] 
    PKC MAPK Ras CaM PKM kinetics[31] PKC MAPK Ras CaM PKM kinetics[32] 
    PKC MAPK Ras CaM PKM kinetics[33] PKC MAPK Ras CaM PKM kinetics[34] 
    PKC MAPK Ras CaM PKM kinetics[35] PKC MAPK Ras CaM PKM kinetics[36] 
    PKC MAPK Ras CaM PKM kinetics[37] PKC MAPK Ras CaM PKM kinetics[38] 
    PKC MAPK Ras CaM PKM 
    This is a 40-compartment reaction-diffusion-transport version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 40 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec In addition, we have a forward (dendrite to soma) transport term of 1 microns/sec. This converts to a rate of 0.1/sec, but applies only to the kf. So the total kf of the diffusion 'reaction' is 0.11 for D = 1 micron^2/sec, and kb is 0.01. If D=0.1 micron^2/sec then kf = 0.101 and kb = 0.001. In addition this model has all molecules buffered in the first and last compartments. This boundary conditions says that the molecules are not drained out of the first compartment, nor do they all pile up in the last one.
    The stimulus file pkm_mapk22_transp_endbuf_D1e-13_Fig4CD which was used for the model to replicate Figure 4C and 4D from the paper.

    GAP acting as a Molecule in  
    Ajay_Bhalla_2007_ReacDiff2 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 687
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 693
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 700
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 705
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 711
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 717
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 723
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 729
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 735
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 741
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 747
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 753
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 759
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 765
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 771
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 777
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 783
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 789
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 795
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 801
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 807
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 813
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 819
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 825
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 831
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 837
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 843
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 849
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 855
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 861
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 867
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 873
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 879
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 885
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 891
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 897
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 903
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 909
    0.00631.5No
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 680
    0.00631.5Yes
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.
    GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 915
    0.00631.5Yes
    GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse.

    GAP acting as an Enzyme in  
    Ajay_Bhalla_2007_ReacDiff2 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 680
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    2GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 687
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    3GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 693
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    4GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 700
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    5GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 705
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    6GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 711
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    7GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 717
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    8GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 723
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    9GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 729
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    10GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 735
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    11GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 741
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    12GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 747
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    13GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 753
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    14GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 759
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    15GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 765
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    16GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 771
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    17GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 777
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    18GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 783
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    19GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 789
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    20GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 795
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    21GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 801
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    22GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 807
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    23GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 813
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    24GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 819
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    25GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 825
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    26GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 831
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    27GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 837
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    28GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 843
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    29GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 849
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    30GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 855
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    31GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 861
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    32GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 867
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    33GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 873
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    34GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 879
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    35GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 885
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    36GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 891
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    37GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 897
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    38GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 903
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    39GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 909
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.
    40GAP /
    GAP-inact-ras
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 915
    1.0104104explicit E-S complexSubstrate
    GTP-Ras

    Product
    GDP-Ras
        From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting.

    GAP acting as a Substrate for an Enzyme in  
    Ajay_Bhalla_2007_ReacDiff2 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    2PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics
    Pathway No. : 684
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    3PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[1]
    Pathway No. : 690
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    4PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[2]
    Pathway No. : 697
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    5PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[3]
    Pathway No. : 694
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    6PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[4]
    Pathway No. : 708
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    7PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[5]
    Pathway No. : 714
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    8PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[6]
    Pathway No. : 720
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    9PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[7]
    Pathway No. : 726
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    10PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[8]
    Pathway No. : 732
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    11PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[9]
    Pathway No. : 738
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    12PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[10]
    Pathway No. : 744
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    13PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[11]
    Pathway No. : 750
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    14PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[12]
    Pathway No. : 756
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    15PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[13]
    Pathway No. : 762
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    16PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[14]
    Pathway No. : 768
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    17PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[31]
    Pathway No. : 870
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    18PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[15]
    Pathway No. : 774
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    19PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[16]
    Pathway No. : 780
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    20PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[17]
    Pathway No. : 786
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    21PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[18]
    Pathway No. : 792
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    22PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[19]
    Pathway No. : 798
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    23PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[20]
    Pathway No. : 804
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    24PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[21]
    Pathway No. : 810
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    25PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[22]
    Pathway No. : 816
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    26PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[23]
    Pathway No. : 822
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    27PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[24]
    Pathway No. : 828
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    28PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[25]
    Pathway No. : 834
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    29PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[26]
    Pathway No. : 840
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    30PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[27]
    Pathway No. : 846
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    31PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[28]
    Pathway No. : 852
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    32PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[29]
    Pathway No. : 858
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    33PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[30]
    Pathway No. : 864
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    34PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[32]
    Pathway No. : 876
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    35PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[33]
    Pathway No. : 882
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    36PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[34]
    Pathway No. : 888
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    37PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[35]
    Pathway No. : 894
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    38PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[36]
    Pathway No. : 900
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    39PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[37]
    Pathway No. : 906
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.
    40PKC-active  /
    PKC-inact-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • kinetics[38]
    Pathway No. : 912
    3.3333344explicit E-S complexSubstrate
    GAP

    Product
    GAP*
        Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review.

    GAP acting as a Substrate in a reaction in  
    Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP

    GAP acting as a Product in a reaction in  
    Ajay_Bhalla_2007_ReacDiff2 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 680
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    3dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 687
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    5dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 693
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    7dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 700
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    9dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 705
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    11dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 711
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    13dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 717
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    15dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 723
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    17dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 729
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    19dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 735
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    21dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 741
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    23dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 747
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    25dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 753
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    27dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 759
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    29dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 765
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    31dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 771
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    33dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 777
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    35dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 783
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    37dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 789
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    39dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 795
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    40diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    41dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 801
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    42diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    43dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 807
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    44diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    45dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 813
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    46diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    47dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 819
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    48diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    49dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 825
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    50diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    51dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 831
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    52diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    53dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 837
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    54diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    55dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 843
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    56diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    57dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 849
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    58diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    59dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 855
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    60diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    61dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 861
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    62diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    63dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 867
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    64diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    65dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 873
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    66diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    67dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 879
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    68diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    69dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 885
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    70diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    71dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 891
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    72diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    73dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 897
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    74diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    75dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 903
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    76diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    77dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 909
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec
    78diff
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff

    Pathway No. : 677
  • 0.101
    (s^-1)
    0.001
    (s^-1)
    Keq = 0.0099(uM)9.804secSubstrate
    GAP

    Product
    GAP
    79dephosph-GAP
  • Ajay_Bhalla_
    2007_ReacDiff2

    Accession No. : 83
  • Ras
    Pathway No. : 915
    0.1
    (s^-1)
    0
    (s^-1)
    --Substrate
    GAP*

    Product
    GAP
      Assume a reasonably good rate for dephosphorylating it, 1/sec



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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