NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for IP3-56Kcmplx

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3-56Kcmplx participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000041

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • NonOsc_Ca_
    IP3metabolism
  • 23Network
    MIPP CaMKII CaM 
    PKC IP3-3K CaRegulation 
    Gq PLCbeta 134_dephos 
    145_dephos IP4-system IHP-system 
    1345_dephos 
    This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3-56Kcmplx acting as a Molecule in  
    NonOsc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3-56Kcmplx
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    01000No
    enzyme substrate complex of IP3 56-K and Ins(134)P3

    IP3-56Kcmplx acting as a Substrate in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • ip4-inhib-56k[1]
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    1
    (uM^-1 s^-1)
    6.3
    (s^-1)
    Kd(bf) = 6.3(uM)-Substrate
    IP3-56Kcmplx
    IP4(1345)

    Product
  • IP4(1345)-56k-cm
    plx

  •   from Shears, JBC 264(33); 1989: 19879-86
    2ip4-inhib-56k
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    1
    (uM^-1 s^-1)
    0.2
    (s^-1)
    Kd(bf) = 0.2(uM)-Substrate
    IP3-56Kcmplx
    IP4(3456)

    Product
  • IP4(3456)-56k-cm
    plx

  •   from Hughes et al, JBC 264(33); 1989: 19871-78
    36kinase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    0.048
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    IP3-56Kcmplx

    Product
    IP3-56K
    IP4(1346)
      Kf = Vmax for IP3 56K from Wilson and Majerus, JBC 271; 1996
    45kinase
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    0.0132
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    IP3-56Kcmplx

    Product
    IP3-56K
    IP4(1345)
      Kf = 0.274 times Vmax of IP3 56-K as product ratio of Ins(1345)P4 : Ins(1346)P4 is 1 : 2.3-5 from Wilson and Majerus, JBC 271; 1996

    IP3-56Kcmplx acting as a Product in a reaction in  
    NonOsc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    IP3-Kcmplx-on
  • NonOsc_Ca_
    IP3metabolism

    Accession No. : 23
  • IP4-system
    Pathway No. : 115
    3
    (uM^-1 s^-1)
    0.192
    (s^-1)
    Kd(bf) = 0.064(uM)-Substrate
    IP3(134)
    IP3-56K

    Product
    IP3-56Kcmplx
    Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from Km and Vmax values provided by Wilson and Majerus, JBC 271; 1996



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.