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Molecule Parameter List for MIPP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*MIPP* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	3	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos, CaRegulation, Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

MIPP acting as a Molecule in Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
MIPP	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	0.398	160	No
Multiple Inositol Polyphosphate Phosphatase from Nogimori et al, JBC 266(25); 1991: 16499-506 MIPP clustered in ER. Distinct transporters present for cytosolic substrates. Accounts for 30-45% of total 3-phosphatase activity against substrates, hence cytosolic counterparts of this enzyme must be present (as per Chi et al, MCB 20; 2000: 6496-507)

MIPP acting as an Enzyme in Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	MIPP / ip5_3pase	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	0.0400005	0.2321	4	explicit E-S complex	Substrate IP5(13456)_ER Product IP4(1456)_ER
	Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991
2	MIPP / ip4_3pase	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	0.13	4.675	4	explicit E-S complex	Substrate IP4(1345)_ER Product IP3(145)_ER
	Ins(1345)P4 3-phosphatase from Nogimori et al, JBC 266; 1991
3	MIPP / ip6_pase	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	0.000299996	0.0132	4	explicit E-S complex	Substrate IP6_ER Product IP5(12456)_ER IP5(13456)_ER
	InsP6 2/3-phosphatase from Nogimori et al, JBC 266; 1991

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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