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Molecule Parameter List for IP3_3K*1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP3_3K*1 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP3_3K*1 acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP3_3K*1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP3-3K
    Pathway No. : 124
    01000No
    Sim et al; JBC 265(18) June 25; 1990: pp 10367-10372 Phos. at 2 major sites = Ser109 & Ser 175; but there is a possibility that inactivation is due to combined effect of multiple phosphorylations activity suppressed by 75%

    IP3_3K*1 acting as an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP3_3K*1 /
    ip3-3k*1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • IP3-3K
    Pathway No. : 124
    1.400040.761874.00003explicit E-S complexSubstrate
    IP3(145)

    Product
    IP4(1345)
    from Sim et al, JBC 265; 1990

    IP3_3K*1 acting as a Product of an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PKC-active  /
    PKC-phos
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • PKC
    Pathway No. : 123
    30.000844explicit E-S complexSubstrate
    IP3_3K

    Product
    IP3_3K*1
    rates referred from standard PKC phosphorylation rates



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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