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Molecule Parameter List for IP2(14)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP2(14) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001200

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP2(14) acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP2(14)
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 145_dephos
    Pathway No. : 128
    01000No
    Hansen et al, Biochimica et Biophysica Acta 1001 (1989) p143 67% of total InsP2 in all tissue slices ~ 5uM Our simulations generate lower basal levels ~0.27 uM because no contribution from phosphatidylinositol lipid degradation is included

    IP2(14) acting as a Substrate for an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP_1pase  /
    ip2_1pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 145_dephos
    Pathway No. : 128
    5.0000524explicit E-S complexSubstrate
    IP2(14)

    Product
    IP1(4)
    from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)

    IP2(14) acting as a Product of an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP3_5pase2  /
    ip3_5pase2
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 145_dephos
    Pathway No. : 128
    18.000410.6673.99991explicit E-S complexSubstrate
    IP3(145)

    Product
    IP2(14)
        from Hansen et al, JBC 262, 1987 activity determined from pH curve. Value scaled 1.5 times to obtain activity at 37C as original experiment was performed at 30C
    2IP_5pase1  /
    ip3_5pase1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 145_dephos
    Pathway No. : 128
    3.000011.14explicit E-S complexSubstrate
    IP3(145)

    Product
    IP2(14)
        Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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