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Molecule Parameter List for CaEPump | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| CaEPump participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
CaEPump acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CaEPump | Osc_Ca_
IP3metabolism
Accession No. : 24 | CaRegulation
Pathway No. : 132 | 0.01 | 1000 | No | | The calcium electrogenic pump: Mc Burney and Neering, TINS 10(4), 1987, 163-169. We treat the pump as a simple Michaelis-Menten enzyme. Levels are constrained tightly by the need to generate Ca oscillations within the Othmer-Tang model. |
CaEPump acting as an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | CaEPump /
Ca-pump-out
| Osc_Ca_
IP3metabolism
Accession No. : 24 | CaRegulation
Pathway No. : 132 | 0.0899977 | 200 | 4 | explicit E-S complex | Substrate
Ca
Product
Ca-ext
| | Both affinity and Vmax of the Ca-pump are higher than those used in the model that generates non-oscillatory Ca dynamics. Km has been decreased from 0.2 to 0.09 uM and Vmax increased from 72 to 200. The parameters are constrained by the need to generate Ca oscillations by the Othmer-Tang model. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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