NCBS Home page
Accession List
Pathway List
Search
Authorized Users
Help
News archives

Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.
Search in: Search for Match By

Molecule Parameter List for activeIP3R

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
activeIP3R participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    activeIP3R acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    activeIP3R
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • Othmer-Tang-mode
    l

    Pathway No. : 133
  • 01000No
    This represents the active IP3 Receptor channel that conducts Ca across the ER membrane in the Othmer-Tang model. Its 0 uM initial concentration represents no active channels present under basal conditions. Its levels build up upon stimulation.

    activeIP3R acting as a Product in a reaction in  
    Osc_Ca_IP3metabolism Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    actIP3R
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • Othmer-Tang-mode
    l

    Pathway No. : 133
  • 1000.01
    (uM^-2 s^-1)
    5
    (s^-1)
    Keq = 0.005(uM)-Substrate
  • mirror_
    Ca.IP3.IP3R

  • mirror_
    Ca.IP3.IP3R

  • mirror_
    Ca.IP3.IP3R


    Product
    activeIP3R
  • Rate set so that almost all Ca.IP3.IP3R complex (formed by Ca and IP3 binding to the IP3R) becomes the active Ca conducting channel



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.