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Accession Type:
Network
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
PKC
MAPK
Ras
CaM
PKM
chain
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[1]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[2]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[3]
PKC
MAPK
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[4]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[5]
PKC
MAPK
Ras
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[6]
CaM
PKM
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[7]
PKC
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[8]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[9]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[10]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[11]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[12]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[13]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[14]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[15]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[16]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[17]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[18]
 Molecule
 Enzyme
 Reaction
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[19]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[20]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[21]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[22]
PKC
MAPK
Ras
CaM
PKM
Shared Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12_[23]
PKC
MAPK
Ras
CaM
PKM

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Molecule List for pathway Shared Object_Ajay_bhalla_2007_ReacDiff1_1e-12[18] (Pathway Number 490)

 Name Initial Conc. (uM) Volume (fL) Buffered
1Ca0.081.5No
2Ca_input0.081.5Yes
3DAG12.21.5Yes
4MAPK*01.5No
5MKP-10.021.5No
    MKP-1 dephosphoryates and inactivates MAPK in vivo: Sun et al Cell 75 487-493 1993. Levels of MKP-1 are regulated, and rise in 1 hour. Kinetics from Charles et al PNAS 90:5292-5296 1993. They refer to Charles et al Oncogene 7 187-190 who show that half-life of MKP1/3CH134 is 40 min. 80% deph of MAPK in 20 min Sep 17 1997: CoInit now 0.4x to 0.0032. See parm searches from jun96 on.
6PKC-active01.5No
7PPhosphatase2A11.5No
    Refs: Pato et al Biochem J 293:35-41(93); Takai&Mieskes Biochem J 275:233-239 k1=1.46e-4, k2=1000,k3=250. these use kcat values for calponin. Also, units of kcat may be in min! revert to Vmax base: k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6 CoInit assumed 0.1 uM. See NOTES for MAPK_Ras50.g. CoInit now 0.08 Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm searches from jun 96 on.

Summed Molecule List

  Target Inputs
1 PKC-activePKC-Ca-memb*
PKC-DAG-memb*
PKM-zeta


Pathway Details  Molecule List   Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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