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Reaction List for pathway RasGTPase (Pathway Number 307) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
GAP_
dissociation | kf
(s^-1) | 1.2
(uM^-1 s^-1) | Kd(cb) = 0.0258(uM) | - | RasGDP_NF1
| RasGDP
NF1
| | | Dissociation of NF1 from Ras.GDP NF1 is a mammalian GAP Kf = 46.5 /sec Kb = 1.2 /sec/uM Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 | | 2 |
GTP_
hydrolysis[1] | kf
(s^-1) | 0.22
(s^-1) | Keq = 0.0113(uM) | 0.051sec | RasGTP-NF1*
| RasGDP-NF1_Pi
| | | First step in hydrolysis of GTP bound to Ras complexed with NF1 - a mammalian GAP Kf = 19.5 /sec Kb = 0.22 /sec Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 | | 3 |
GTP_
hydrolysis[2] | kf
(s^-1) | 0.0001
(uM^-1 s^-1) | Kd(cb) = 0(uM) | - | RasGDP-NF1_Pi
| Pi
RasGDP_NF1
| | | Second step in hydrolysis of GTP bound to Ras is complexed with NF1 - a mammalian GAP Kf = 40 /sec Kb = 108 /M/sec = 1.08e-04 /uM/sec Phillips RA et al 2003 Biochemistry 42: 3956-3965 | | 4 |
NF1_binding | kf
(uM^-1 s^-1) | 6.36
(s^-1) | Kd(bf) = 5.3(uM) | - | RasGTP
NF1
| RasGTP-NF1
| | | Binding of NF1 to Ras.GTP NF1 is a mammalian GAP Kd = 5.3 uM Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 | | 5 |
Ras_activation | kf
(s^-1) | 5.5
(s^-1) | Keq = 0.0132(uM) | 0.002sec | RasGTP-NF1
| RasGTP-NF1*
| | | Activation of Ras by GAP (i.e NF1) Kf = 418 /sec Kb = 5.5 /sec Table 3, Phillips RA et al 2003 Biochemistry 42: 3956-3965 |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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