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Accession Type:
Network
Osc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos
CaRegulation
Othmer-Tang-mode
l
 Molecule
 Enzyme
 Reaction

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Molecule List for pathway Othmer-Tang-model (Pathway Number 133)

 Name Initial Conc. (uM) Volume (fL) Buffered
1activeIP3R01000No
    This represents the active IP3 Receptor channel that conducts Ca across the ER membrane in the Othmer-Tang model. Its 0 uM initial concentration represents no active channels present under basal conditions. Its levels build up upon stimulation.
2Ca.IP3.IP3R01000No
    IP3-IP3Receptor complex with Ca bound at the activating site.
3Ca2.IP3.IP3R01000No
    THe Ca-IP3-IP3Receptor complex with additional Ca bound to the inhibitory sites. This is the inactive state of the channel.
4ER_leak21000No
    The channel that leaks Ca from the stores to the cytoplasm This channel is not sensitive to any potential differences. Channel permeability is 0.1, as used in the O-T model (Tang et al, Biophys J 70, 1996)
5ER_pump21000No
    This pump represents the ATP-dependent pump that moves cytosolic Ca into the ER in the Othmer-Tang model.
6IP30.21000No
    Inositol(145)trisphosphate in the cytoplasm. Levels are determined by the IP3-metabolism network
7IP3.IP3R01000No
    IP3 Receptor with IP3 bound. This state does not conduct Ca as per Tang et al, Biophys J 70; 1996
8IP3R0.11000No
    IP3 Receptor with no ligand bound
9mirror_Ca.IP3.IP3R01000No
   

Summed Molecule List

  Target Inputs
1 IP3IP3(145)
Inositol(145)trisphosphate in the cytoplasm. Levels are determined by the IP3-metabolism network
2 mirror_Ca.IP3.IP3RCa.IP3.IP3R


Pathway Details  Molecule List   Enzyme List   Reaction List  


Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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