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Accession Type:
Network
Osc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
 Molecule
 Reaction
PKC
IP3-3K
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos
CaRegulation
Othmer-Tang-mode
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Molecule List for pathway CaM (Pathway Number 160)

 Name Initial Conc. (uM) Volume (fL) Buffered
1CaM201000No
    LOT of this present in the cell: upto 1% of total protein mass. (Alberts et al, Mol Biol of the Cell, Garland Publishers) says 25 uM. Meyer et al, Science 256; 1992: 1199-1202 refer to studies saying it is comparable to CaMK levels. (Kakiuchi et al, J Biochem 92; 1982; 1041-48) say conc in cerebral cortex & cerebellum homogenates: 20-30uM Lower conc in other tissues: lung, adrenal gland, liver, kidney, spleen = 6,5,5,3,2 uM respectively
2CaM-Ca301000No
    The TR1 end now begins to bind Ca. This form has 2 Ca's on the TR2 end, and one on the TR1.
3CaM-Ca401000No
    The four-calcium-bound form of CaM. It is the active form for most reactions.
4CaM-TR2-Ca201000No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.


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