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Accession Type:
Network
Ajay_Bhalla_
2004_Feedback_
Tuning
Shared_Object_
Ajay_Bhalla_
2004_Feedback_
Tuning
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
 Molecule
 Enzyme
 Reaction
Sos
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC

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Molecule List for pathway EGFR (Pathway Number 354)

 Name Initial Conc. (uM) Volume (fL) Buffered
1EGF01.5Yes
2EGFR0.16671.5No
    Berkers et al JBC 266 say 22K hi aff recs. Sherrill and Kyte Biochemistry 35 use range 4-200 nM. These match, lets use them.
3Internal_L.EGFR01.5No
4L.EGFR01.5No
    This is terribly simplified: there are many interesting intermediate stages, including dimerization and assoc with adapter molecules like Shc, that contribute to the activation of the EGFR.
5SHC0.51.5No
    There are 2 isoforms: 52 KDa and 46 KDa (See Okada et al JBC 270:35 pp 20737 1995). They are acted up on by the EGFR in very similar ways, and apparently both bind Grb2 similarly, so we'll bundle them together here. Sasaoka et al JBC 269:51 pp 32621 1994 show immunoprecs where it looks like there is at least as much Shc as Grb2. So we'll tentatively say there is 1 uM of Shc.
6SHC*01.5No


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