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Reaction List for pathway sGC (Pathway Number 69) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
act_sGCfast | kf
(s^-1) | 0.2
(s^-1) | Keq = 0.01(uM) | 0.05sec | NO.SGC_6coord
| NO.sGC_5coord
| | | Rates used directly from Stone and Marletta,1996,Biochemistry, 35(4):1093-1099. | | 2 |
act_sGCslow | kf
(s^-1) | 0.02
(s^-1) | Keq = 0.0125(uM) | 0.617sec | nonhemebind_int
| NO.sGC5accord
| | | Rates used directly from Stone and Marletta,1996, Biochemistry, 35(4):1093-1099. | | 3 |
form6coord | kf
(s^-1) | 0
(s^-1) | - | - | NO.sGCslow
| NO.sGC6coord
| | | Rates used directly from Stone and Marletta,1996, Biochemistry, 35(4):1093-1099. | | 4 |
form_6coord | kf
(s^-1) | 0
(s^-1) | - | - | NO.sGCfast
| NO.SGC_6coord
| | | Rates used directly from Stone and Marletta,1996,Biochemistry, 35(4):1093-1099. | | 5 |
NObindnonheme | kf
(uM^-1 s^-1) | 25
(s^-1) | Kd(bf) = 5(uM) | - | NO.sGC6coord
NO
| nonhemebind_int
| | | This step is the one that differs from the fast reaction scheme, as reported by Stone and Marletta. Here the reaction is dependent upon the binding of NO to an unidentified non-heme site on the protein. Rates used directly from Stone and Marletta,1996, Biochemistry, 35(4):1093-1099. | | 6 |
NO_bind_sGCfast | kf
(uM^-1 s^-1) | 800
(s^-1) | Kd(bf) = 1.1429(uM) | - | sGCfast
NO
| NO.sGCfast
| | | This is the fast binding of NO to sGC, subsequently activating it, as proposed by Stone and Marletta. Rates of these binding reactions used directly from Stone and Marletta,1996, Biochemistry, 35(4):1093-1099, based on whose paper this model is made. Rates obtained from stopped flow kinetics detailed in their paper. | | 7 |
NO_bind_sGCslow | kf
(uM^-1 s^-1) | 800
(s^-1) | Kd(bf) = 1.1429(uM) | - | sGCslow
NO
| NO.sGCslow
| | | This is the slow binding of NO to sGC, as reported by Stone and Marletta,1996, Biochemistry, 35(4):1093-1099.The rates shown have been used directly from their data from stopped flow kinetics. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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