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Molecule Parameter List for PA

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

PA participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
PLCbeta1	13	Pathway	PLCbeta
This is a model of PLCbeta1 in the bovine brain membranes as stimulated by Ca, Gq and PA. The primary data sources are Irene Litosch Biochemistry (2000) 39(26):7736-43, Sternweis PC et al. Philos Trans R Soc Lond B Biol Sci. (1992) 336(1276):35-41 and Smrcka AV et al. Science (1991) 251(4995):804-7.

PA acting as a Molecule in PLCbeta1 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PA	PLCbeta1 Accession No. : 13	PLCbeta Pathway No. : 67	1	0.0016667	No
12 Jul 2001 The Concentration of Phosphatidic Acid is obtained from I. Liotsch, Biochem., 2000, 39, 7736-7743. The PA concentration vary between 0-60uM Usually the concn levels are set to the basal levels which are under 2 mole percent, estimated at 1 uM.

PA acting as a Substrate in a reaction in PLCbeta1 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PA-bind-Ca.PLCbe ta	PLCbeta1 Accession No. : 13	PLCbeta Pathway No. : 67	1 (uM^-1 s^-1)	8 (s^-1)	Kd(bf) = 8(uM)	-	Substrate Ca.PLCbeta PA Product PA.Ca.PLCbeta
6 Nov 2001 The Kf and Kb values were fixed according to the dose response curves obtained from I. Litosch, Biochem., 2000, 39, 7736-7743.

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