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Molecule Parameter List for Gq.Ca.PLCbeta | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gq.Ca.PLCbeta participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 0 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| PLCbeta1 | 13 | Pathway | PLCbeta |
| This is a model of PLCbeta1 in the bovine brain membranes as stimulated by Ca, Gq and PA. The primary data sources are Irene Litosch Biochemistry (2000) 39(26):7736-43, Sternweis PC et al. Philos Trans R Soc Lond B Biol Sci. (1992) 336(1276):35-41 and Smrcka AV et al. Science (1991) 251(4995):804-7. | |||
Gq.Ca.PLCbeta acting as a Molecule in PLCbeta1 Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| Gq.Ca.PLCbeta | PLCbeta1 Accession No. : 13 | PLCbeta Pathway No. : 67 | 0 | 0.0016667 | No | |
| 6 Nov 2001 This active enzyme is complex formed by binding of Gq with Ca.PLCbeta where concentration formed is 0 because of the absence of Gq.The response curves are obtained in the absence of Gq by I.Litosch, Biochem. 2000, 39,7736-7743. | ||||||
Gq.Ca.PLCbeta acting as an Enzyme in PLCbeta1 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| Gq.Ca.PLCbeta / Gq.Ca.PLCbeta | PLCbeta1 Accession No. : 13 | PLCbeta Pathway No. : 67 | 10 | 23 | 4 | explicit E-S complex | Substrate PIP2 Product DAG IP3 |
| 3 Nov 2001 The Km and Vmax values are fixed accordingly from Sternweis et al Phil Trans R Soc Lond B Bio Sci 1992 Apr 29;336(1276):35-41;discussion 41-2 and Smrcka et al Science 251 804-807 1991 where Km varied between 5 and 20uM and Vmax between 7 and 23 umol/min/mg depending on the presenece and absence of Gq. | |||||||
Gq.Ca.PLCbeta acting as a Product in a reaction in PLCbeta1 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
ta | PLCbeta1 Accession No. : 13 | PLCbeta Pathway No. : 67 | 50 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.02(uM) | - | Substrate Ca.PLCbeta Gq Product Gq.Ca.PLCbeta |
| 6 Nov 2001 The Kf and Kb values were fixed according to the response curves obtained from I. Litosch, Biochem., 2000, 39, 7736-7743. | |||||||