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Molecule Parameter List for CaM.PDE1 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig3_CaMKII | 2 | Network |
Shared_Object_fig3_CaMKII, CaMKII, CaM,
PP1, PP2B, PKA,
AC | This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse.
Demonstration script files for generating the figures in the paper, including figure 3, are available here. |
CaM.PDE1 acting as a Molecule in fig3_CaMKII Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CaM.PDE1 | fig3_CaMKII
Accession No. : 2 | AC
Pathway No. : 18 | 0 | 1000 | No | | |
CaM.PDE1 acting as an Enzyme in fig3_CaMKII Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | CaM.PDE1 /
CaM.PDE1
| fig3_CaMKII
Accession No. : 2 | AC
Pathway No. : 18 | 39.6825 | 10 | 4 | explicit E-S complex | Substrate
cAMP
Product
AMP
|
CaM.PDE1 acting as a Product in a reaction in fig3_CaMKII Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | CaM_bind_PDE1 | fig3_CaMKII
Accession No. : 2 | AC
Pathway No. : 18 | 720
(uM^-1 s^-1) | 5
(s^-1) | Kd(bf) = 0.0069(uM) | - | Substrate
CaM-Ca4
PDE1
Product
CaM.PDE1
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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