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Molecule Parameter List for IP2(14)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP2(14) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP2(14) acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP2(14)	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	0	1000	No
Hansen et al, Biochimica et Biophysica Acta 1001 (1989) p143 67% of total InsP2 in all tissue slices ~ 5uM Our simulations generate lower basal levels ~0.27 uM because no contribution from phosphatidylinositol lipid degradation is included

IP2(14) acting as a Substrate for an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP_1pase  / ip2_1pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	5.00005	2	4	explicit E-S complex	Substrate IP2(14) Product IP1(4)
from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)

IP2(14) acting as a Product of an Enzyme in  NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP3_5pase2  / ip3_5pase2	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	18.0004	10.667	3.99991	explicit E-S complex	Substrate IP3(145) Product IP2(14)
	from Hansen et al, JBC 262, 1987 activity determined from pH curve. Value scaled 1.5 times to obtain activity at 37C as original experiment was performed at 30C
2	IP_5pase1  / ip3_5pase1	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	3.00001	1.1	4	explicit E-S complex	Substrate IP3(145) Product IP2(14)
	Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987