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Molecule Parameter List for IP4(3456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP4(3456) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	0	2	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP4(3456) acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP4(3456)	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1.4	1000	No
Inositol (3456)tetrakisphosphate basal levels ~ 1.4uM

IP4(3456) acting as a Substrate for an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP4-1K  / ip4-1k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.359995	0.598	4	explicit E-S complex	Substrate IP4(3456) Product IP5(13456)
from Tan et al, JBC 272; 1997

IP4(3456) acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	ip4-inhib-56k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate IP3-56Kcmplx IP4(3456) Product IP4(3456)-56k-cm plx
	from Hughes et al, JBC 264(33); 1989: 19871-78
2	IP4-inhib-3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	1345_dephos Pathway No. : 117	1 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.5(uM)	-	Substrate 1345_3pase IP4(3456) Product IP4-3pase-cmplx
	from Hoer et al, Biochem J 270; 1990

IP4(3456) acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
ip5-1-pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.0031 (s^-1)	0 (s^-1)	-	-	Substrate IP5(13456) Product IP4(3456)
most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80