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Molecule Parameter List for IP6-K

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP6-K participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP6-K acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP6-K	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	0.008	1000	No
from Voglmaier et al, PNAS 93; 1996: 4305-10 has InsP5 kinase/ PP-InsP4 synthase and PP-InsP4 kinase apart from InsP6 kinase activity (Saiardi et al, JBC 275(32); 2000: 24686-92)

IP6-K acting as an Enzyme in  NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP6-K / ip5_k1	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	6.69999	0.234	4	explicit E-S complex	Substrate IP5(13456) Product PP-IP4
	from Saiardi et al, JBC 275(32); 2000: 24686-92
2	IP6-K / pp-ip4-k1	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	23.0003	0.05	4	explicit E-S complex	Substrate PP-IP4 Product bisPP-IP3
	from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants

IP6-K acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
IP6cmplx-on	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	0.0038 (uM^-2 s^-1)	2.376 (s^-1)	-	-	Substrate ATP IP6 IP6-K Product IP6-K-complex
from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction

IP6-K acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
IP6cmplx-off	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	1.26 (s^-1)	0.0012 (uM^-2 s^-1)	-	-	Substrate IP6-K-complex Product ADP IP6-K PP-IP5
from Voglmaier et al, PNAS 93; 1996 Kf = Vmax of forward reaction Kb calculated from Km for InsP6 and ATP, and Vmax of forward and backward reactions