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Molecule Parameter List for IP5(13456)_ER

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP5(13456)_ER participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP5(13456)_ER acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP5(13456)_ER	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	0	160	No

IP5(13456)_ER acting as a Substrate for an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
MIPP  / ip5_3pase	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	0.0400005	0.2321	4	explicit E-S complex	Substrate IP5(13456)_ER Product IP4(1456)_ER
Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991

IP5(13456)_ER acting as a Product of an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
MIPP  / ip6_pase	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	0.000299996	0.0132	4	explicit E-S complex	Substrate IP6_ER Product IP5(12456)_ER IP5(13456)_ER
InsP6 2/3-phosphatase from Nogimori et al, JBC 266; 1991

IP5(13456)_ER acting as a Substrate in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
ip5(13456)_trp	Osc_Ca_ IP3metabolism Accession No. : 24	MIPP Pathway No. : 120	1 (s^-1)	0.001 (s^-1)	Not applicable**	-	Substrate IP5(13456)_ER Product IP5(13456)
Ins(13456)P5 ER-cytosol transport

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration