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Molecule Parameter List for IP3_3K_CaM*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP3_3K_CaM* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	2	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP3_3K_CaM* acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3_3K_CaM*	Osc_Ca_ IP3metabolism Accession No. : 24	IP3-3K Pathway No. : 124	0	1000	No
8-10 fold activation with both CaM bound and CaMKII phosphorylation (phos at thr311) Communi et al; EMBO J 16 (8), pp 1943-1952, 1997

IP3_3K_CaM* acting as an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP3_3K_CaM* / ip3-3k-CaM*	Osc_Ca_ IP3metabolism Accession No. : 24	IP3-3K Pathway No. : 124	2.80002	45	4	explicit E-S complex	Substrate IP3(145) Product IP4(1345)
from Communi et al, EMBO J 16; 1997 Vmax adjusted to obtain 9-fold greater activity than ip3-3k

IP3_3K_CaM* acting as a Product of an Enzyme in  Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII  / CaM-CaMK-phos1	Osc_Ca_ IP3metabolism Accession No. : 24	CaMKII Pathway No. : 121	1.59998	0.5	4	explicit E-S complex	Substrate IP3_3K_CaM Product IP3_3K_CaM*
	rates referred from standard CaM-CaMKII phosphorylation rates
2	tot_autonomous_ CaMKII  / CaMK-phos1	Osc_Ca_ IP3metabolism Accession No. : 24	CaMKII Pathway No. : 121	2.49995	0.5	4	explicit E-S complex	Substrate IP3_3K_CaM Product IP3_3K_CaM*
	rates referred from standard CaMKII phosphorylation rates

IP3_3K_CaM* acting as a Product in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
3K*-bind-CaM	Osc_Ca_ IP3metabolism Accession No. : 24	IP3-3K Pathway No. : 124	49.9998 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.002(uM)	-	Substrate CaM-Ca4 IP3_3K* Product IP3_3K_CaM*
Communi et al, EMBO J 16; 1997 phosphorylated 3kinase has 25 fold greater sensitivity to CaM binding than the non-phosphorylated enzyme (Kd of 2nM)