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Molecule Parameter List for IP2(14) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP2(14) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP2(14) | Osc_Ca_
IP3metabolism
Accession No. : 24 | 145_dephos
Pathway No. : 128 | 0 | 1000 | No | | Hansen et al, Biochimica et Biophysica Acta 1001 (1989) p143 67% of total InsP2 in all tissue slices ~ 5uM Our simulations generate lower basal levels ~0.27 uM because no contribution from phosphatidylinositol lipid degradation is included |
IP2(14) acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP_1pase /
ip2_1pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | 145_dephos
Pathway No. : 128 | 5.00005 | 2 | 4 | explicit E-S complex | Substrate
IP2(14)
Product
IP1(4)
| | from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14) |
IP2(14) acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP3_5pase2 /
ip3_5pase2 | Osc_Ca_
IP3metabolism
Accession No. : 24 | 145_dephos
Pathway No. : 128 | 18.0004 | 10.667 | 3.99991 | explicit E-S complex | Substrate
IP3(145)
Product
IP2(14)
| | | from Hansen et al, JBC 262, 1987 activity determined from pH curve. Value scaled 1.5 times to obtain activity at 37C as original experiment was performed at 30C | | 2 | IP_5pase1 /
ip3_5pase1 | Osc_Ca_
IP3metabolism
Accession No. : 24 | 145_dephos
Pathway No. : 128 | 3.00001 | 1.1 | 4 | explicit E-S complex | Substrate
IP3(145)
Product
IP2(14)
| | | Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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