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Molecule Parameter List for IP4(3456) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP4(3456) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP4(3456) | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 1.4 | 1000 | No | | Inositol (3456)tetrakisphosphate basal levels ~ 1.4uM |
IP4(3456) acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP4-1K /
ip4-1k | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.359995 | 0.598 | 4 | explicit E-S complex | Substrate
IP4(3456)
Product
IP5(13456)
| | from Tan et al, JBC 272; 1997 |
IP4(3456) acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
IP4(3456) acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | ip5-1-pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.0031
(s^-1) | 0
(s^-1) | - | - | Substrate
IP5(13456)
Product
IP4(3456)
| | most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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