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Molecule Parameter List for PP-IP5

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PP-IP5 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	2	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

PP-IP5 acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP-IP5	Osc_Ca_ IP3metabolism Accession No. : 24	IHP-system Pathway No. : 130	2	1000	No
Diphosphoinositol pentakisphosphate Conc from Huang et al, Biochem 37; 1998

PP-IP5 acting as a Substrate for an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
DIPP1  / dipp_ip7	Osc_Ca_ IP3metabolism Accession No. : 24	IHP-system Pathway No. : 130	0.340006	5.1	4	explicit E-S complex	Substrate PP-IP5 Product IP6
from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of recombinant human protein which is 20-50 fold greater than activity of the purified rat enzyme

PP-IP5 acting as a Product of an Enzyme in  Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP6_K2  / ip6_k2	Osc_Ca_ IP3metabolism Accession No. : 24	IHP-system Pathway No. : 130	2.99999	1.633	4	explicit E-S complex	Substrate IP6 Product PP-IP5
	from Saiardi et al, Curr Biol 9; 1999
2	DIPP1  / dipp_ip8	Osc_Ca_ IP3metabolism Accession No. : 24	IHP-system Pathway No. : 130	0.0340035	0.6165	4	explicit E-S complex	Substrate bisPP-IP4 Product PP-IP5
	from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of human recombinant protein, which is 20-50 fold greater than activity of the purified rat enzyme

PP-IP5 acting as a Substrate in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
PP-IP5cmplx-on	Osc_Ca_ IP3metabolism Accession No. : 24	IHP-system Pathway No. : 130	0.0027 (uM^-2 s^-1)	2.5 (s^-1)	-	-	Substrate ATP PP-IP5 PP-IP5-K Product PP-IP5-K-complex
from Huang et al, Biochem 37; 1998 Kf calculated using Km for PP-InsP5 and ATP, and Vmax of forward and backward reactions. Kb = Vmax of backward reaction

PP-IP5 acting as a Product in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
IP6cmplx-off	Osc_Ca_ IP3metabolism Accession No. : 24	IHP-system Pathway No. : 130	1.26 (s^-1)	0.0012 (uM^-2 s^-1)	-	-	Substrate IP6-K-complex Product ADP IP6-K PP-IP5
from Voglmaier et al, PNAS 93; 1996 Kf = Vmax of forward reaction Kb calculated from Km for InsP6 and ATP, and Vmax of forward and backward reactions