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Molecule Parameter List for inositol

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

inositol participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	2	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

inositol acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
inositol	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	500	1000	Yes

inositol acting as a Product of an Enzyme in  Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP1_pase  / ip1_4pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	190	39.33	4	explicit E-S complex	Substrate IP1(4) Product inositol
	Ins(4)P1 4-phsophatase from Gee et al, BiochemJ 249; 1988
2	IP1_pase  / ip1_1pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	160.001	11.43	4	explicit E-S complex	Substrate IP1(1) Product inositol
	from Gee et al, Biochem J 249; 1988

inositol acting as a Product in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
IP1(3)_deg	Osc_Ca_ IP3metabolism Accession No. : 24	134_dephos Pathway No. : 127	35 (s^-1)	0 (s^-1)	-	-	Substrate IP1(3) Product inositol
rate based on levels of Ins(3)P1