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Molecule Parameter List for COHb | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| COHb participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | CO_activation_
of_GC | 28 | Pathway |
sGC | Carbon Monoxide is an activator of soluble Guanylyl Cyclase and has been implicated as a neuronal messenger [Ingi T. et al. Neuron (1996) 16(4):835-42].
CO binds to the heme group on sGC, similar to NO binding. Exogenous CO at similar conc. to endogenous levels were used to study the extent of activation of GC. Olfactory receptor neurons were used by Ingi et al., to investigate the relationship of CO to cGMP levels, as these cells have high levels of HO activity but no NOS activity.
Kharitonov VG. et al. Proc Natl Acad Sci U S A. (1995) 92(7):2568-71 and
Kharitonov VG. et al. Biochemistry (1999) 38(33):10699-706 report the presence of a six coordinate and a five coordinate intermediate of carboxy GC, induced by CO. Considering that activation of sGC by CO is similar in almost all tissues, some rates have been taken from original published works cited as references in Kharitonov et al., and Ingi et al., the primary datasources, this model is based on. |
COHb acting as a Molecule in CO_activation_of_GC Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | COHb | CO_activation_
of_GC
Accession No. : 28 | sGC
Pathway No. : 140 | 0 | 0.0016667 | No | | Carboxy Hemoglobin, from which CO subsequently is released into the alveolar space of the lung, where molecular oxygen is alternately bound to the heme. Most of the CO generated in the body is thus exhaled into the airway. (Suematsu M, personal correspondence) |
COHb acting as a Product in a reaction in CO_activation_of_GC Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | CObindsHbO2 | CO_activation_
of_GC
Accession No. : 28 | sGC
Pathway No. : 140 | 0.17
(uM^-1 s^-1) | 0.0078
(s^-1) | Kd(bf) = 0.0459(uM) | - | Substrate
Ery_HbO2
dissoCO
Product
COHb
| | CO binds to hemoglobin, predominantly the erythrocyte associated hemoglobin. The affinity of hemoglobin for CO is 200-250 times that of oxygen, while relative affinities of heme proteins (myoglobin), cytochrome oxidase and cytochrome P-450 for CO are much lower. CO binds reversibly to hemoglobin to form Carboxy hemoglobin, (COHb) from which CO is exhaled through the lungs. Primary source for rates, Migita et al., JBC, 1998, 273(2): 945-949, and refs cited in their paper. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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