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Molecule Parameter List for Raf-GTP-Ras* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | fig4_synapse | 3 | Network | Shared_Object_fig4_synapse, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, CaMKII, CaM, PP1, PP2B, PKA, AC | This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here. |
Raf-GTP-Ras* acting as a Molecule in fig4_synapse Network
Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | Raf-GTP-Ras* | fig4_synapse Accession No. : 3 | MAPK Pathway No. : 24 | 0 | 1000 | No | |
Raf-GTP-Ras* acting as an Enzyme in fig4_synapse Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | 1 | Raf-GTP-Ras* / Raf-GTP-Ras*.1
| fig4_synapse Accession No. : 3 | MAPK Pathway No. : 24 | 0.159091 | 0.105 | 4 | explicit E-S complex | Substrate MAPKK
Product MAPKK-ser
| 2 | Raf-GTP-Ras* / Raf-GTP-Ras*.2
| fig4_synapse Accession No. : 3 | MAPK Pathway No. : 24 | 0.159091 | 0.105 | 4 | explicit E-S complex | Substrate MAPKK-ser
Product MAPKK*
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Raf-GTP-Ras* acting as a Product in a reaction in fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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