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Molecule Parameter List for R2C2-cAMP3 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig4_synapse | 3 | Network |
Shared_Object_fig4_synapse, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, CaMKII, CaM,
PP1, PP2B, PKA,
AC | This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here. |
R2C2-cAMP3 acting as a Molecule in fig4_synapse Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | R2C2-cAMP3 | fig4_synapse
Accession No. : 3 | PKA
Pathway No. : 30 | 0 | 1000 | No | | R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 3 cAMP molecules bound to it. |
R2C2-cAMP3 acting as a Substrate in a reaction in fig4_synapse Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | cAMP-bind-site-A
2 | fig4_synapse
Accession No. : 3 | PKA
Pathway No. : 30 | 75
(uM^-1 s^-1) | 32.5
(s^-1) | Kd(bf) = 0.4333(uM) | - | Substrate
R2C2-cAMP3
cAMP
Product
R2C2-cAMP4
| | Now cAMP shows effects of cooperativity and PKA has a low Kd for cAMP. |
R2C2-cAMP3 acting as a Product in a reaction in fig4_synapse Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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