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Molecule Parameter List for R2C-cAMP4 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | fig4_synapse | 3 | Network | Shared_Object_fig4_synapse, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, CaMKII, CaM, PP1, PP2B, PKA, AC | This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here. |
R2C-cAMP4 acting as a Molecule in fig4_synapse Network
Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | R2C-cAMP4 | fig4_synapse Accession No. : 3 | PKA Pathway No. : 30 | 0 | 1000 | No | R-dimer bound to 4 cAMP molecules. |
R2C-cAMP4 acting as a Substrate in a reaction in fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | Release-C2 | fig4_synapse Accession No. : 3 | PKA Pathway No. : 30 | 60 (s^-1) | 18 (uM^-1 s^-1) | Kd(cb) = 0.3(uM) | - | Substrate R2C-cAMP4
Product PKA-active R2-cAMP4
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R2C-cAMP4 acting as a Product in a reaction in fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | Release-C1 | fig4_synapse Accession No. : 3 | PKA Pathway No. : 30 | 60 (s^-1) | 18 (uM^-1 s^-1) | Kd(cb) = 0.3(uM) | - | Substrate R2C2-cAMP4
Product PKA-active R2C-cAMP4
| The complex starts to dissociate and release catalytic subunit C. This has to be fast, as the activation of PKA by cAMP is also fast. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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