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Molecule Parameter List for R2C-cAMP4

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
R2C-cAMP4 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse PKC PLA2 
PLCbeta Gq MAPK 
Ras CaMKII CaM 
PP1 PP2B PKA 
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

R2C-cAMP4 acting as a Molecule in  
fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
R2C-cAMP4fig4_synapse
Accession No. : 3
PKA
Pathway No. : 30
01000No
R-dimer bound to 4 cAMP molecules.

R2C-cAMP4 acting as a Substrate in a reaction in  
fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Release-C2fig4_synapse
Accession No. : 3
PKA
Pathway No. : 30
60
(s^-1)
18
(uM^-1 s^-1)
Kd(cb) = 0.3(uM)-Substrate
R2C-cAMP4

Product
PKA-active
R2-cAMP4

R2C-cAMP4 acting as a Product in a reaction in  
fig4_synapse Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Release-C1fig4_synapse
Accession No. : 3
PKA
Pathway No. : 30
60
(s^-1)
18
(uM^-1 s^-1)
Kd(cb) = 0.3(uM)-Substrate
R2C2-cAMP4

Product
PKA-active
R2C-cAMP4
The complex starts to dissociate and release catalytic subunit C. This has to be fast, as the activation of PKA by cAMP is also fast.



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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