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Molecule Parameter List for temp-PIP2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
temp-PIP2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000020

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig4_synapse3Network
Shared_Object_fig4_synapse,  PKC,  PLA2,  
PLCbeta,  Gq,  MAPK,  
Ras,  CaMKII,  CaM,  
PP1,  PP2B,  PKA,  
AC 
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper.
Demonstration script files for generating the figures in the paper, including figure 4, are available here.

temp-PIP2 acting as a Molecule in  fig4_synapse Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
temp-PIP2fig4_synapse
Accession No. : 3
  • Shared_Object_
    fig4_synapse
    Pathway No. : 19
    		• 2.51000Yes

    temp-PIP2 acting as a Substrate in a reaction in      fig4_synapse Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1PIP2-PLA2-actfig4_synapse
    Accession No. : 3    		PLA2
    Pathway No. : 21    		0.0012
    (uM^-1 s^-1)    		0.5
    (s^-1)    		Kd(bf) = 416.6667(uM)-Substrate
    PLA2-cytosolic
    temp-PIP2

    Product
    PIP2-PLA2*
    2
  • PIP2-Ca-PLA2-act
    		• fig4_synapse
    Accession No. : 3    		PLA2
    Pathway No. : 21    		0.012
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 8.3333(uM)-Substrate
    PLA2-Ca*
    temp-PIP2

    Product
    PIP2-Ca-PLA2*


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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