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Molecule Parameter List for PKC-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PKC-active participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	6	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig4_synapse	3	Network	Shared_Object_fig4_synapse,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here.

PKC-active acting as a Molecule in  fig4_synapse Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKC-active	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	0.02	1000	No

PKC-active acting as a Summed Molecule in  fig4_synapse Network

Accession Name	Pathway Name	Target	Input
fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	PKC-active	PKC-DAG-AA* PKC-Ca-memb* PKC-Ca-AA* PKC-DAG-memb* PKC-basal* PKC-AA*

PKC-active acting as an Enzyme in  fig4_synapse Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKC-active / PKC-act-raf	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	66.6667	4	4	explicit E-S complex	Substrate craf-1 Product craf-1*
2	PKC-active / PKC-inact-GAP	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	3.33333	4	4	explicit E-S complex	Substrate GAP Product GAP*
3	PKC-active / PKC-act-GEF	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
4	PKC-active / PKC-phosph-neuro granin	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	28.6275	0.58	4.03448	explicit E-S complex	Substrate neurogranin Product neurogranin*
5	PKC-active / PKC-phosph-ng-Ca M	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	28.5948	0.35	4	explicit E-S complex	Substrate neurogranin-CaM Product CaM neurogranin*
6	PKC-active / phosph-AC2	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	33.3333	4	4	explicit E-S complex	Substrate AC2 Product AC2*