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Molecule Parameter List for IP1(4) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | NonOsc_Ca_
IP3metabolism | 31 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, CaRegulation,
Gq, PLCbeta, 134_dephos,
145_dephos, IP4-system, IHP-system,
1345_dephos | | This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP1(4) acting as a Molecule in NonOsc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP1(4) | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | 145_dephos
Pathway No. : 153 | 0 | 1000 | No | | Inositol 4-monophosphate Basal levels = 10% of Ins(1)P1 ~ 4uM Ackermann et al, BiochemJ 242, 1987(2): 517 |
IP1(4) acting as a Product of an Enzyme in NonOsc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP_1pase /
ip2_1pase | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | 145_dephos
Pathway No. : 153 | 5.00005 | 2 | 4 | explicit E-S complex | Substrate
IP2(14)
Product
IP1(4)
| | from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14) |
IP1(4) acting as a Substrate in a reaction in NonOsc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 4pase-on | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | 145_dephos
Pathway No. : 153 | 1.035
(uM^-1 s^-1) | 157.32
(s^-1) | Kd(bf) = 152(uM) | - | Substrate
IP1(4)
IP1_pase
Product
ip1_4pase_cmplx
| | Rates derived from Ins(4)P1 4-phosphatase Km: Gee et al, Biochem J 249; 1988 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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