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Molecule Parameter List for IP4(3456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP4(3456) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	2	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	31	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP4(3456) acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP4(3456)	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP4-system Pathway No. : 154	1.4	1000	No
Inositol (3456)tetrakisphosphate basal levels ~ 1.4uM

IP4(3456) acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	ip4-1k-on	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP4-system Pathway No. : 154	31.2001 (uM^-1 s^-1)	2.496 (s^-1)	Kd(bf) = 0.08(uM)	-	Substrate IP3-56K_IP4-1K IP4(3456) Product ip4_1k_cmplx
	Rates derives from enzyme Km and Vmax values: Yang and Shears, Biochem J 2000, 351: 551-555.
2	IP4-inhib-3pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	1345_dephos Pathway No. : 156	1 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.5(uM)	-	Substrate 1345_3pase IP4(3456) Product IP4-3pase-cmplx
	from Hoer et al, Biochem J 270; 1990

IP4(3456) acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
ip5_1pase	NonOsc_Ca_ IP3metabolism Accession No. : 31	IP4-system Pathway No. : 154	0.0136 (s^-1)	0 (s^-1)	-	-	Substrate IP5(13456) Product IP4(3456)
InsP5 1-phosphatase Reaction is necessary to generate the flux of Ins(3456)P4 seen physiologically (Ho et al Curr Biol 2002, 12:1-20), although the IP4-1K/pase can maintain basal levels of this InsP4.