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Molecule Parameter List for ip4_3k_cmplx | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | NonOsc_Ca_
IP3metabolism | 31 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, CaRegulation,
Gq, PLCbeta, 134_dephos,
145_dephos, IP4-system, IHP-system,
1345_dephos | | This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
ip4_3k_cmplx acting as a Molecule in NonOsc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | ip4_3k_cmplx | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | IP4-system
Pathway No. : 154 | 0 | 1000 | No | | Enzyme complex exclusively modeled to include reversible kinetics, as the back flux is significant for dG = -10 kJ/mol |
ip4_3k_cmplx acting as a Substrate in a reaction in NonOsc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | ip4-3k-off | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | IP4-system
Pathway No. : 154 | 4.3
(s^-1) | 0.2687
(uM^-1 s^-1) | Kd(cb) = 0.0625(uM) | - | Substrate
ip4_3k_cmplx
Product
IP4-3K
IP5(13456)
| | Kf = Vmax for enzyme: Stephens et al, Biochem J 249; 1988. Kb ascertained from dG calculations for equilibrium conditions. |
ip4_3k_cmplx acting as a Product in a reaction in NonOsc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | ip4-3k-on | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | IP4-system
Pathway No. : 154 | 53.7501
(uM^-1 s^-1) | 17.2
(s^-1) | Kd(bf) = 0.32(uM) | - | Substrate
IP4(1456)
IP4-3K
Product
ip4_3k_cmplx
| | Rates derived from Km for enzyme: Stephens et al, Biochem J 249; 1988. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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