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Molecule Parameter List for IP6-K-complex | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | NonOsc_Ca_
IP3metabolism | 31 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, CaRegulation,
Gq, PLCbeta, 134_dephos,
145_dephos, IP4-system, IHP-system,
1345_dephos | | This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. It is similar to the NonOsc_Ca_IP3metab model (accession 23) except that some enzymes have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. These modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP6-K-complex acting as a Molecule in NonOsc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP6-K-complex | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | IHP-system
Pathway No. : 155 | 0 | 1000 | No | | enzyme substrate complex of InsP6 kinase and InsP6 |
IP6-K-complex acting as a Substrate in a reaction in NonOsc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | IP6cmplx-off | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | IHP-system
Pathway No. : 155 | 1.26
(s^-1) | 0.0012
(uM^-2 s^-1) | - | - | Substrate
IP6-K-complex
Product
ADP
IP6-K
PP-IP5
| | from Voglmaier et al, PNAS 93; 1996 Kf = Vmax of forward reaction Kb calculated from Km for InsP6 and ATP, and Vmax of forward and backward reactions |
IP6-K-complex acting as a Product in a reaction in NonOsc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | IP6cmplx-on | NonOsc_Ca_
IP3metabolism
Accession No. : 31 | IHP-system
Pathway No. : 155 | 0.0038
(uM^-2 s^-1) | 2.376
(s^-1) | - | - | Substrate
ATP
IP6
IP6-K
Product
IP6-K-complex
| | from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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