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Molecule Parameter List for 3kCaM_ip3_cmplx | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
3kCaM_ip3_cmplx acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | 3kCaM_ip3_cmplx | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP3-3K
Pathway No. : 162 | 0 | 1000 | No | | Enzyme complex exclusively modeled because enzymes is reversible, unlike M-M enzymes. Reversibility determined from dG calculations. |
3kCaM_ip3_cmplx acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 3k-CaM-off | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP3-3K
Pathway No. : 162 | 10.5
(s^-1) | 0.0968
(uM^-1 s^-1) | Kd(cb) = 0.0092(uM) | - | Substrate
3kCaM_ip3_cmplx
Product
IP3_3K_CaM
IP4(1345)
| | Kf = Vmax for enzyme: Erneux et al, Biochem 214; 1993 Enzyme is 2-2.5 fold more active than basal enzyme. Kb derived from equilibrium conditions for dG = -10 kJ/mol |
3kCaM_ip3_cmplx acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 3k-CaM-on | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP3-3K
Pathway No. : 162 | 18.7497
(uM^-1 s^-1) | 42.001
(s^-1) | Kd(bf) = 2.2401(uM) | - | Substrate
IP3(145)
IP3_3K_CaM
Product
3kCaM_ip3_cmplx
| | rates from Km for enzyme: Erneux et al, Biochem 214; 1993 Enzyme is 2-2.5 fold more active than ip3-3k, but Km is doubled. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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