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Molecule Parameter List for IP_4pase | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP_4pase acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP_4pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 0.9 | 1000 | No | | from Norris et al, JBC 269(12); 1994: 8716-20 Enzyme conc increased from 9 nM to 0.9 uM to obtain appreciable enzyme activity has two 4-phosphatase activities: against Ins(134)P3 and Ins(34)P2 respectively |
IP_4pase acting as an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP_4pase /
ip3_4pase
| Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 20.0014 | 20 | 4 | explicit E-S complex | Substrate
IP3(134)
Product
IP2(13)
| | | Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2 | | 2 | IP_4pase /
ip2_4pase
| Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 22.9995 | 55 | 4 | explicit E-S complex | Substrate
IP2(34)
Product
IP1(3)
| | | Ins(34)P2 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994 |
IP_4pase acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | IP_4pase-inact | Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 1
(uM^-1 s^-1) | 19
(s^-1) | Kd(bf) = 19(uM) | - | Substrate
IP6
IP_4pase
Product
IP_4pase_inact
| | from Norris et al, JBC 269; 1994 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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