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Molecule Parameter List for bisPP-IP4 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
bisPP-IP4 acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | bisPP-IP4 | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 2 | 1000 | No | | Bis(diphospho)inositol tetrakisphosphate Conc from Huang et al, Biochem 37; 1998 |
bisPP-IP4 acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | DIPP1 /
dipp_ip8 | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 0.0340035 | 0.6165 | 4 | explicit E-S complex | Substrate
bisPP-IP4
Product
PP-IP5
| | from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of human recombinant protein, which is 20-50 fold greater than activity of the purified rat enzyme |
bisPP-IP4 acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | PP-IP5cmplx-off | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 1
(s^-1) | 0.0013
(uM^-2 s^-1) | - | - | Substrate
PP-IP5-K-complex
Product
ADP
PP-IP5-K
bisPP-IP4
| | from Huang et al, Biochem 37; 1998 Kf = Vmax of forward reaction Kb calculated using Km for PP-InsP5 and ATP, and Vmax of forward and backward reactions |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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