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Molecule Parameter List for inositol | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
inositol acting as a Molecule in Osc_Ca_IP3metabolism Network
inositol acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | ip1_syn | Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 0.11
(s^-1) | 0
(s^-1) | - | - | Substrate
inositol
Product
IP1(1)
| | This rxn. maintains levels of Ins(1)P1 at 44 uM basal. Actually, 90% of Ins(1)P1 is generated from PtdIns degradation (Ackermann et al, Biochem J 242(2), 1987: 517-24) but for simplicity we use a back rxn. from Inositol to generate this conc. |
inositol acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | IP1(3)_deg | Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 35
(s^-1) | 0.336
(s^-1) | Keq = 0.0096(uM) | 0.028sec | Substrate
IP1(3)
Product
inositol
| | | Kf and Kb based on levels of Ins(3)P1. Kb necessary as energetics calculations show backflow from inositol to be significant. | | 2 | 1pase-off | Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 11.43
(s^-1) | 0.0008
(uM^-1 s^-1) | Kd(cb) = 0.0001(uM) | - | Substrate
ip1_1pase_cmplx
Product
IP1_pase
inositol
| | | Kf = Vmax for Ins(1)P1-1phosphatase: Gee et al, Biochem J 249, 1988. Kb necessary as estimated from percent inositol backflux calculations. This contributes to maintain Ins(1)P1 at 10% of its actual pool. | | 3 | 4pase-off | Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 39.33
(s^-1) | 0.0021
(uM^-1 s^-1) | Kd(cb) = 0.0001(uM) | - | Substrate
ip1_4pase_cmplx
Product
IP1_pase
inositol
| | | Kf = Vmax for Ins(4)P1 4-phosphatase: Gee et al, Biochem J 249, 1988. Kb adjusted to generate reported basal levels of Ins(4)P1 = 10% of Ins(1)P1 ~ 4uM |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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