| Name | mkp1_feedback_effects |
| Accession Type | Network |
| Transcriber | Upinder S. Bhalla, NCBS |
| Developer | Upinder S. Bhalla, NCBS |
| Entry Date (YYYY-MM-DD) | 2001-11-07 00:00:00 |
| Species | Generic mammalian |
| Tissue | NIH 3T3 Expression |
| Cell Compartment | Surface - nucleus |
| Source | Bhalla US et al. Science (2002) 297(5583):1018-23. ( peer-reviewed publication ) |
| Methodology | Quantitative match to experiments |
| Model Implementation | Exact GENESIS implementation |
| Model Validation | Replicates orginal data, Quantitatively predicts new data |
| Notes | This is a network involving the MAPK-PKC feedback loop with input from the PDGFR in the synapse. The distinctive feature of this model is that it includes MKP-1 induction by MAPK, and the consequent inhibitory regulation of MAPK and the feedback loop. Lots of interesting dynamics arise from this. This link provides supplementary material for the paper Bhalla US et al. Science (2002) 297(5583):1018-23. In the form of several example simulations and demos for the figures in the paper. |
