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Molecule Parameter List for A1A2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

A1A2 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
MAPK_Asthagiri_ adapt_fb	45	Pathway	MAPK
This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

A1A2 acting as a Molecule in  MAPK_Asthagiri_adapt_fb Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
A1A2	MAPK_Asthagiri_ adapt_fb Accession No. : 45	MAPK Pathway No. : 193	0	390	No
Adaptor protein heterodimer from Asthagiri and Lauffenburger 2001.

A1A2 acting as a Substrate in a reaction in  MAPK_Asthagiri_adapt_fb Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
C*-bind-A1A2	MAPK_Asthagiri_ adapt_fb Accession No. : 45	MAPK Pathway No. : 193	5.0001 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate A1A2 C* Product E0*
Kf12 and Kr12 are 3*10^8 M-1 min-1 and 0.5/sec from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

A1A2 acting as a Product in a reaction in  MAPK_Asthagiri_adapt_fb Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
A1-bind-A2	MAPK_Asthagiri_ adapt_fb Accession No. : 45	MAPK Pathway No. : 193	5.0001 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate A1 A2 Product A1A2
Kc12 and Kd12 are 3*10^8 M-1 min-1 and 0.5/sec from Asthagiri and Lauffenburger 2001.