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Molecule Parameter List for CaMKII***

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKII*** participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_2003	49	Network	Shared_Object_CaMKII_2003,  CaMKII,  CaM,   PP1,  PP2B
Model of regulation of CaMKII by Calcium, including parallel excitatory input from CaM and inhibitory input from PP1 as regulated by Calcineurin and PKA. Cell type: neuronal. Bhalla US. Biophys J. 2004 Aug;87(2):733-44.

CaMKII*** acting as a Molecule in  CaMKII_2003 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII***	CaMKII_2003 Accession No. : 49	CaMKII Pathway No. : 202	0	1000	No
From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.

CaMKII*** acting as a Summed Molecule in  CaMKII_2003 Network

Accession Name	Pathway Name	Target	Input
CaMKII_2003 Accession No. : 49	CaMKII Pathway No. : 202	tot_autonomous_CaMKII	CaMKII-thr286 CaMKII***

CaMKII*** acting as a Substrate for an Enzyme in  CaMKII_2003 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active  / Deph-thr305	CaMKII_2003 Accession No. : 49	Shared_Object_ CaMKII_2003 Pathway No. : 201	5.09907	0.35	4	explicit E-S complex	Substrate CaMKII*** Product CaMKII-thr286
2	PP1-active  / Deph-thr286c	CaMKII_2003 Accession No. : 49	Shared_Object_ CaMKII_2003 Pathway No. : 201	5.09907	0.35	4	explicit E-S complex	Substrate CaMKII*** Product CaMK-thr306

CaMKII*** acting as a Product of an Enzyme in  CaMKII_2003 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII  / CaM_act_305	CaMKII_2003 Accession No. : 49	CaMKII Pathway No. : 202	113.6	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_autonomous_ CaMKII  / auton_305	CaMKII_2003 Accession No. : 49	CaMKII Pathway No. : 202	175.003	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	See Hanson and Schulman again, for afterburst rates of phosph.