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Molecule Parameter List for ShP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

ShP participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	1	0	1	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_Signaling_ pathway	52	Pathway	EGFR
This model is based on the model and parameters published in paper: Quantification of Short Term Signaling by the EGFR Kholodenko et al, The J Biol Chem. , Vol 274, No. 42, Issue of October 15, pp. 30169 - 30181, 1999. Note: There are a few small ambiguities in the paper about initial conditions employed for obtaining the results. Thanks to Dr. Kholodenko for clarifying those ambiguities and providing the values used in the simulations:[G-S]=33.04579, [Grb]=51.95431, [SOS]=0.95421.

ShP acting as a Molecule in  EGFR_Signaling_pathway Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
ShP	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0	1.6667E-6	No
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

ShP acting as a Summed Molecule in  EGFR_Signaling_pathway Network

Accession Name	Pathway Name	Target	Input
EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	pShctot	R-ShP R-Sh-G R-Sh-G-S ShP Sh-G Sh-G-S
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81. Total phosphorylated Shc = [ShP] + [Sh-G] + [ Sh-G-S] + [R-ShP] [R-Sh-G] + [R-Sh-G-S]

ShP acting as a Substrate for an Enzyme in  EGFR_Signaling_pathway Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
enz16  / r16	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.34	1.7	4	Classical Michaelis-Menten V = Etot.S.Kcat/Km+S	Substrate ShP Product Shc
Taken from Kholodenko et al 1999.

ShP acting as a Substrate in a reaction in  EGFR_Signaling_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
r21	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	3 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0333(uM)	-	Substrate Grb ShP Product Sh-G
Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.

ShP acting as a Product in a reaction in  EGFR_Signaling_pathway Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	r15	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.3 (s^-1)	0.9 (uM^-1 s^-1)	Kd(cb) = 3(uM)	-	Substrate R-ShP Product RP ShP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.
2	r23	EGFR_Signaling_ pathway Accession No. : 52	EGFR Pathway No. : 223	0.1 (s^-1)	21 (uM^-1 s^-1)	Kd(cb) = 210(uM)	-	Substrate Sh-G-S Product G-S ShP
	Taken from Kholodenko BN et al J Biol Chem. (1999) 274(42):30169-81.