Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Search in:

ALL Accession Pathway Molecule Enzyme Reaction Connected to

Search for

Match

Anything Exact Word Starting With

By

Name Notes Model

Molecule Parameter List for PPhosphatase2A

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PPhosphatase2A participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	4	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
EGFR_MAPK	58	Network	Shared_Object_EGFR_MAPK,  MAPK,  Ras,   EGFR,  Sos
Model of MAPK activation by EGFR in the synapse. Demonstration programs using this model are available here. Primary citation:Bhalla US. Biophys J. (2004) 87(2):745-53.

PPhosphatase2A acting as a Molecule in  EGFR_MAPK Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PPhosphatase2A	EGFR_MAPK Accession No. : 58	Shared_Object_ EGFR_MAPK Pathway No. : 229	0.224	1000	No
Refs: Pato et al Biochem J 293:35-41(93); Takai&Mieskes Biochem J 275:233-239 k1=1.46e-4, k2=1000,k3=250. these use kcat values for calponin. Also, units of kcat may be in min! revert to Vmax base: k3=6, k2=25,k1=3.3e-6 or 6,6,1e-6 CoInit assumed 0.1 uM. See NOTES for MAPK_Ras50.g. CoInit now 0.08 Sep 17 1997: Raise CoInt 1.4x to 0.224, see parm searches from jun 96 on.

PPhosphatase2A acting as an Enzyme in  EGFR_MAPK Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PPhosphatase2A / craf-deph	EGFR_MAPK Accession No. : 58	Shared_Object_ EGFR_MAPK Pathway No. : 229	15.6566	6	4.16667	explicit E-S complex	Substrate craf-1* Product craf-1
	See parent PPhosphatase2A for parms
2	PPhosphatase2A / MAPKK-deph	EGFR_MAPK Accession No. : 58	Shared_Object_ EGFR_MAPK Pathway No. : 229	15.6566	6	4.16667	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser
	See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
3	PPhosphatase2A / MAPKK-deph-ser	EGFR_MAPK Accession No. : 58	Shared_Object_ EGFR_MAPK Pathway No. : 229	15.6566	6	4.16667	explicit E-S complex	Substrate MAPKK-ser Product MAPKK
4	PPhosphatase2A / craf**-deph	EGFR_MAPK Accession No. : 58	Shared_Object_ EGFR_MAPK Pathway No. : 229	15.6566	6	4.16667	explicit E-S complex	Substrate craf-1** Product craf-1*
	Ueki et al JBC 269(22) pp 15756-15761 1994 show hyperphosphorylation of craf, so this is there to dephosphorylate it. Identity of phosphatase is not known to me, but it may be PP2A like the rest, so I have made it so.