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Molecule Parameter List for CaMKII***

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

CaMKII*** participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	0	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model0	59	Network	Shared_Object_AMPAR_traff_model0, CaMKII, CaM, PP1, PP2B, PP1_PSD, PKA, AC, AMPAR, AMPAR_memb
This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

CaMKII*** acting as a Molecule in AMPAR_traff_model0 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII***	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	0	0.09	No
From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.

CaMKII*** acting as a Summed Molecule in AMPAR_traff_model0 Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	tot_autonomous_CaMKII	CaMKII-thr286 CaMKII*** basal_CaMKII_ cyt
2	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	tot_CaMKII_cyt	CaMKII-CaM CaMKII-thr286-C aM CaMKII-thr286 CaMKII** CaMK-thr305 CaMKII basal_CaMKII_ cyt

CaMKII*** acting as a Substrate for an Enzyme in AMPAR_traff_model0 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active / Deph-thr305	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII* Product** CaMKII-thr286
2	PP1-active / Deph-thr286c	AMPAR_traff_ model0 Accession No. : 59	PP1 Pathway No. : 237	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII* Product** CaMK-thr305

CaMKII*** acting as a Product of an Enzyme in AMPAR_traff_model0 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII / CaM_act_305	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	113.601	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_autonomous_ CaMKII / auton_305	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	175	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	See Hanson and Schulman again, for afterburst rates of phosph.

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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