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Molecule Parameter List for neurogranin-CaM_PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
neurogranin-CaM_PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model0
    		• 59Network
    Shared_Object_AMPAR_traff_model0,  CaMKII,  CaM,  
    PP1,  PP2B,  PP1_PSD,  
    PKA,  AC,  AMPAR,  
    AMPAR_memb 
    This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

    neurogranin-CaM_PSD acting as a Molecule in      AMPAR_traff_model0 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    neurogranin-CaM_PSD
  • AMPAR_traff_
    model0
    Accession No. : 59
    		• CaM
    Pathway No. : 236    		00.01No

    neurogranin-CaM_PSD acting as a Substrate for an Enzyme in      AMPAR_traff_model0 Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    PKC-active  /

  • PKC-phosph-ng-Ca
    M_
    PSD
  • AMPAR_traff_
    model0
    Accession No. : 59
  • Shared_Object_
    AMPAR_traff_
    model0
    Pathway No. : 234
    		• 28.59560.354explicit E-S complexSubstrate

  • neurogranin-CaM_
    PSD

    Product
    CaM-PSD
  • neurogranin*_
    PSD
    • Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993

    neurogranin-CaM_PSD acting as a Product in a reaction in      AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents

  • neurogranin-bind
    -CaM_
    PSD
  • AMPAR_traff_
    model0
    Accession No. : 59
    		• CaM
    Pathway No. : 236    		0.3
    (uM^-1 s^-1)    		1
    (s^-1)    		Kd(bf) = 3.3333(uM)-Substrate
    CaM-PSD
    neurogranin_PSD

    Product

  • neurogranin-CaM_
    PSD
    • Surprisingly, no direct info on rates from neurogranin at this time. These rates are based on GAP-43 binding studies. As GAP-43 and neurogranin share near identity in the CaM/PKC binding regions, and also similarity in phosph and dephosph rates, I am borrowing GAP-43 kinetic info. See Alexander et al JBC 262:13 6108-6113 1987


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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